Myeloproliferative

MYELOPROLIFERATIVE DISORDERS www.freelivedoctor.com

Hematopoietic Neoplasms overview ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Lymphoid vs Myelogenous ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Acute vs Chronic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Acute vs Chronic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Blood/BM vs Tissue ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

“ leukoproliferative disorders” ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

myeloid neoplasms ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Myeloproliferative Disorders (old classification) ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Chronic Myeloproliferative Disorders (new WHO classification) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Chronic Myelogenous Leukemia (CML) ,[object Object],[object Object],[object Object],[object Object],[object Object],Philadelphia chromosome t(9;22) www.freelivedoctor.com

Chronic Myelogenous Leukemia (CML) laboratory ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Chronic Myelogenous Leukemia (CML) clinical ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Polycythemia Vera (PV) ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Polycythemia Vera (PV) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Polycythemia Vera (PV) diagnostic criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Essential Thrombocythemia ,[object Object],[object Object],[object Object],[object Object],arrow: macrothrombocyte www.freelivedoctor.com

Essential Thrombocythemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Myelofibrosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Myelofibrosis Aniso-poikilocytosis leukemoid reaction “ naked” nuclear fragments www.freelivedoctor.com

Acute Myelogenous Leukemia (AML) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Acute Myelogenous Leukemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

AML clinical symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

AML physical findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Acute Myelogenous Leukemia (AML) peripheral blood smear ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

AML hematologic findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Acute Myelogenous Leukemia (AML) special stains ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

AML classification ,[object Object],[object Object],www.freelivedoctor.com

Acute Myelogenous Leukemia (AML) WHO classification (2001) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],≥ 20% myeloblasts in blood and/or bone marrow = AML positive myeloperoxidase reaction in >3% of blasts = AML (↔ ALL) www.freelivedoctor.com

Acute Myelogenous Leukemia (AML) FAB classification (1985) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

M0 : Minimally Differentiated Acute Myelogenous Leukemia ,[object Object],www.freelivedoctor.com peroxidase negative

M1 : Acute Myeloblastic Leukemia without Maturation ,[object Object],[object Object],www.freelivedoctor.com

M2 : Acute Myeloblastic Leukemia with Maturation ,[object Object],[object Object],[object Object],www.freelivedoctor.com

M3 : Acute Promyelocytic Leukemia ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

M4 : Acute Myelomonocytic Leukemia ,[object Object],[object Object],[object Object],www.freelivedoctor.com

M5 : Acute Monocytic Leukemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

M6 : Erythroleukemia ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

M7 : Acute Megakaryoblastic Leukemia ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Acute Myelogenous Leukemia (AML) prognostic factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Myeloproliferative

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